A
drug commonly prescribed to diabetics could make bones thinner and more fragile. The discovery could explain why diabetics are at increased osteoporisis risk of fractures.New research suggests that treating diabetes long-term basis Rosiglitazone, sold under the brand name Avandia, is likely to lead to osteoporosis. The diabetes is used to stimulate response to insulin.
Some American researchers have discovered in laboratory mice, that the drug speeds up the activity of cells that cause bone loss, said a report released online at the website of Nature Medicine.
Avandia has recently been cautioned about the risk of heart failure in some patients. GlaxoSmithKline, which markets the drug, has already acknowledged that a study had found an increased osteoporosis risk of fracture in women taking the drug. But the latest report is the first to attempt to explain the relationship between diabetes and fractures.
This discovery will better understand the challenges associated with long-term treatment of patients with type 2 diabetes, and guide the development of a "new generation" of drugs to eliminate this side effect, according to the authors of the report .
The research was funded by the Howard Hughes Medical Institute and the National Institutes of Health.
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