T
he study by researchers at the University and University Hospital Geneva highlights the correlation between men osteoporosis and changes in gene sequence LRP5, said Le Temps in an article published on May 18.The results of research conducted with 889 people (approximately 50% of men and 50% female), were published in The American Journal of Human Genetics this month.
Among men with osteoporosis, LRP5 gene responsible for the synthesis of a protein found on cells that allow the creation bone (osteoblasts) was amended. This link is not verifiable in women.
Two adjacent studies were conducted on 350 children and over a hundred men over 50 suffer from osteoporosis early. They have to verify the results.
According to the World Health Organization, osteoporosis is a major health problem among seniors. Caused by the loss of bone density and alteration of the micro-architecture of bones, this disease is responsible for numerous fractures, especially hip, spine and wrist.
During his life one in two women may be affected by osteoporosis, an osteoporosis caused by a decrease in estrogen after menopause and the constant rate of corticosteroids. In humans, the genetic factors that explain the disease of fragile bones. It can also result from the treatment or the failure of certain glands.
This new discovery could help identify people at risk but the remark Professor Ferrari, co-responsible for the study, "it is always difficult to replace the natural product of a gene with a drug. We are moving towards a therapy nevertheless a new genre. "
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