I
t is well known for years that "the high-dose cortisone, widely prescribed against asthma, rheumatoid arthritis and other inflammatory diseases weakens the skeleton." Why? An early response comes from the USA.In fact, it would appear that this hormone acts directly on cells responsible for bone: osteoblasts, which are builders bone, and osteoclasts that remove old bone.
A team of the Faculty of Medicine at Washington University (St. Louis, USA) worked on different lines of genetically engineered mice. It reached conclusions suprenantes.
According to this work indeed, cortisone cause of self osteoblasts, inhibiting the contrary, the destructive power of osteoclasts.
A good news, because they are destroying the bones? Not necessarily. Because of the coup, "the process of renewal of the skeleton is blocked. And the bones are weakened under the combined effects of ageing and stress" suggest the authors.
For the first time, this is a rational explanation to the main side effect of corticosteroids. It remains to penetrate the molecular mechanism. This is the only way to develop - maybe! -- Against an attack and enhance the safety of these treatments
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